PHARMACOLOGIST and TOXICOLOGIST
212 N. Central Ave. (scroll down or click to see CV and PUBLICATIONS)
Fairborn, OH 45324
Phone/Fax: (937)878-5531
Secure Fax: (320)923-8174
e-mail:
or
JANUSZB@AOL.COM
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underlined hypertext to send e-mail or connect to other
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*Lactational transfer of chemicals
*A seminar on pharmacokinetic modeling in infants and developing children
Summary: health risk assessments; extensive
experience in research and teaching of toxicology, pharmacology, biochemical
effects, and mechanisms of action, pharmacokinetics, disposition of chemicals
in biological systems, risk assessment and mathematical modeling (PBPK/PD).
Many publications. Diplomate of the American Board of Toxicology,
Inc.
EDUCATION
1998 D.A.B.T. - General Toxicology
American Board of Toxicology, Inc., Raleigh, NC, USA
1975 - 1979 D.Sc. - Biochemical Pharmacology
Academy of Medicine, School of Pharmacy: Gdansk, Poland
1970 - 1975 Ph.D. - Pharmacology-Pharmaceutical Sciences
Academy of Medicine, School of Pharmacy: Gdansk, Poland
1965 - 1970 M.Sc. - Toxicology-Pharmaceutical Sciences
Academy of Medicine, School of Pharmacy: Gdansk, Poland
1970 Licensed Pharmacist: Gdansk, Poland
* HOBBY
Traditional American Music: Folk, Bluegrass, Dixieland, Barbershop Harmony
Acoustic Instruments: Banjo, Guitar, Autoharp, Mandolin, Balalaika
* CONTINUING EDUCATION
RECENT:
2008 - TERA - Dose-Response Assessment Boot Camp, Cincinnati, OH, March 31 - April 4, 2008.
2007 - Clu-In/U.S. EPA Research and Development: "Human Health and Ecological Risk Assessment with Spatial Analysis and Decision Assistance (SADA) Freeware" - On-line August 7, 2007.
2007 - SafeX, Health, Safety and Environmental Training Program: "CFR 1910.120; 8-hr Refresher training course for hazardous waste operations". Columbus, OH, May 10, 2007.
2007 - ITRC/U.S. EPA - Risk Assessment and Risk Management: "Determination and Application of Risk-Based Values" Internet-Based 2.5 hrs Training Course, March 27, 2007.
LINK TO COMPLETE LIST OF CONTINUING EDUCATION
EXPERIENCE:
2000 - present Specialist, Environmental Risk Assessment Coordinator
DERR, Ohio EPA
Columbus, Ohio
1999 - present
Independent
Consultant
Fairborn, Ohio
1998 - 1999 Consultant and Senior Toxicologist
TN & Associates, Inc.
Consulting Engineers,
Cincinnati, Ohio
1991 - 1998 Project Scientist & Study Director
ManTech Environmental Technology, Inc.,
Armstrong
Laboratory, Wright-Patterson
Air
Force Base, Ohio
1991 - 1994 Consultant
Pharmaceutical Specialties, Inc.,
Tampa, Florida
1987 - 1991 Asst. Professor & Research Scientist
Toxicology Program, College of Public Health,
University of South Florida,
Tampa, Florida
1985 -1987 Cancer Research Scientist
Depart. Experimental Therapeutics,
Roswell Park
Memorial Institute,
Buffalo, New York
1983 - 1984 Pharmacologist & Director of Pharmacy,
Sabbatical
International Red Cross and Red Crescent,
Tobruk, Libya
1980 - 1983 Tenured Member of Faculty of Medicine
& Adjunct Professor of Pharmacology
Academy of Medicine,
Gdansk, Poland
1979 - 1980 Cancer Research Scientist
Dept. of Experimental Therapeutics,
Roswell Park
Memorial Institute,
Buffalo, N.Y.
1978 - 1979 Senior Lecturer of Pharmacology & Senior Research
Scientist
Dept. of Pharmacology, Institute of Pathology,
Academy of Medicine,
Gdansk, Poland.
1974 - 1978 Lecturer of Pharmacology & Research Scientist
Dept. of Pharmacology,
Academy of Medicine,
Gdansk, Poland.
1970 - 1974 Research & Teaching Scientist
Dept. of Biochemistry,
Academy of Medicine,
Gdansk, Poland.
1970 - 1971 Part time Pharmacist
Public Pharmacy,
Gdansk, Poland.
1967 - 1970 Research Assistant, Student
Dept. of Toxicology,
School of Pharmacy,
Academy of Medicine,
Gdansk, Poland.
CAPABILITIES:
* Direct and supervise pharmaceutical and toxicological studies
* Conduct and prepare risk assessments and mathematical modeling of chemical disposition
* Create and review research proposals and write protocols
* Prepare and edit toxicity reviews, research reports and manuscripts for publication
* Solve problems in a creative way
* Search publications and maintain computerized data bases
* Write codes for PBPK/PD models in ACSL, SCoP, and Simusolv advanced computer programming languages
* Develop physiologically based pharmacokinetic models (PBPK, PBPD) and run computer simulations
* Research and develop laboratory techniques
HANDS-ON EXPERIENCE IN THE FOLLOWING TECHNIQUES:
* TOXICOLOGY AND RISK ASSESSMENT:
Health risk assessment, site-specific risk assessments, exposure
characterizations, derivation of toxicity values,
RfD, RfC, Cancer SF/UR,
Bio-Transfer Factor (BTF), etc.
Monitoring physiological response of animals, ED50, LD50, inhalation exposures: open and closed chambers; assessing mode of action in vivo and in vitro;
Risk assessments and mathematical modeling of chemical distribution; lactational transfer of xenobiotics.
* BIOCHEMICAL TOXICOLOGY:
Methods of
enzyme
isolation, kinetics and mechanisms of inhibition; immunoelectrophoresis of protein and preparation of antisera;
Preparation of subcellular organelles;
Measurement of thermogenesis and bioenergetic parameters of mitochondria, oxidative phosphorylation, polarography, O2-electrode, prostaglandin beta-oxidation, K+-electrode, shrinkage-swelling of organelle, electron microscopy, membrane aggregation, lipid oxidation; UV-VIS spectrophotometry;
Microsomal metabolism of radioactive xenobiotics (14C, 3H), activation-inactivation of carcinogens and lipid peroxidation; TLC, GC and HPLC;
Precision cut liver slices, EPR - spin trapping of free radicals, lipid peroxidation;
* COMPUTERS:
Computer applications and modeling (Microsoft Office, word and data
processing, spreadsheets,
statistics, graphics,
ACSL, SCoP,
on-line
bibliography -
search);
MAC (graphics),
VAX/VMS/PC
(ACSL, SIMUSOLV:
PBPK/PD modeling);
INTERNET: writing HTML codes; World Wide Web searching.
ACCOMPLISHMENTS:
* Lectured students of Pharmacy, Dentistry, Medicine & Public Health
* Instructed students on Toxicology, Biochemistry & Pharmacology
* Designed and/or directed 12 major research projects and 6 research grants
* Wrote 72 peer-reviewed publications and numerous technical reports, presented 117 abstracts and 58 seminars
* Wrote multiple Technical Reports, 5 Invited Review Papers, 3 chapters in Advances in Environmental Sciences and Technology series, 3 Textbook Chapters: 1 on Hepatotoxicity, 1 on Pharmacokinetic/Dynamic Modeling and 1 on Mathematical Modeling in Elemental Speciation
* Has been elected a councilor of the Ohio Chapter of Society for Risk Analysis in 1994.
* Was invited as an expert reviewer U.S. EPA and ATSDR, member of Ph.D. committee Georgia Institute of Technology, Atlanta, GA, expert Expert Resources, Inc.
* Received 4 scientific awards:
Research Award (First Degree) for "Outstanding Achievements in Science for Young Scientists" by The Scientific Society of Gdansk in 1975.
Research Award (Second Degree) for "Investigations on DDT" by Polish Pharmacological Society in 1977.
Research Award (First Degree) for "Investigations on Thermogenesis" by The Ministry of Health and Social Welfare of Poland in 1977.
Travel Grant from Society for Research on Polyunsaturated Fatty Acids to present study on "Lipid Peroxidation and Benzo(a)pyrene Cooxygenation" in Tokyo, Japan, 1992.
* His biography has been published by:
1. Dabrowska, D.: Habilitacja: Dr hab. farm. Janusz Byczkowski. Farmacja Polska 39 (11), 688-689, 1983.
2. "Who's Who" Environmental Registry, In the Environmental Industry, USA, 1992.
3. "Who's Who in the Midwest", Edit.1994-97, 2000-01, Marquis Who's Who, New Providence, NJ, USA.
4. "Who's Who in Science and Engineering", Edit.1994-97, 2000-07, Marquis Who's Who, New Providence, NJ.
5. "Who's Who in America", Edit.1997, 2001-07, Marquis Who's Who, New Providence, NJ, USA.
6. "Who's Who in the World", Edit.1995-97, 2000-07, Marquis Who's Who, New Providence, NJ, USA.
7. "Who's Who in Medicine and Healthcare" Edit.1996, 200-07, Marquis Who's Who, New Providence, NJ, USA.
8. "Who's Who in Polish America", 1st Edit.1996-1997, Bicentennial Publishing Corp. New York, NY.
9. "Men of Achievement" 17th Edit.1996-1997, International Biographical Centre, Cambridge, UK.
* Served as Editorial and Peer Reviewer for the Following Journals and Agencies:
1. Toxicology and Industrial Health
2. Bulletin of Environmental Contamination and Toxicology
3. Free Radical Biology and Medicine
4. Archives of Environmental Contamination and Toxicology
5. Placenta
7. Toxicology and Applied Pharmacology
8. Ecotoxicology and Environmental Safety
10. U.S. EPA Integrated Risk Information System (IRIS)
12. U.S. CDC Agency for Toxic Substances and Disease Registry
13. Eastern Research Group, Inc. (ERG)
* Participated as Member in the Following Societies:
Society of Toxicology (Full Member)
International Society for Free Radical Research
The American Board of Forensic Examiners (Member listed in Natl Registr)
Society for Research of Polyunsaturated Fatty Acids
American Museum of Natural History
American Association for the Advancement of Science
The New York Academy of Sciences
Society for Risk Analysis (elected Councilor of Ohio Chapter 1994-96)
Graduate Faculty of the University of S. Florida (nominated Associate Member till 1996)
* Directed (as a P.I.) or contributed as a Co-P.I. in the following major
RESEARCH PROJECTS:
* C U R R E N T R E S E A R C H :
Lipid Peroxidation in the Liver; Physiologically Based Pharmacokinetic and Pharmacodynamic Modeling;
Computer Simulation of Toxicokinetics and Toxicodynamics; Hepatocarcinogenesis, Mechanistic and Stochastic Mathematical Modeling of Free Radical Reactions and their Biological Effects;
Developmental Toxicology and Lactational Transfer of Chemicals;
Risk Assessment of Trichloroethylene, Perchloroethylene and their Metabolites; Pharmacokinetics of Methylmercury and Cadmium;
Derivation of Toxicity Values (RfC, RfD, BMD) Using U.S. EPA Methodology;
Consulting U.S. EPA and Other Agencies on Issues in Toxicology and Risk Assessment.
PUBLICATIONS:
* PEER-REVIEWED ARTICLES:
1. Byczkowski,S., Byczkowski,J.Z.& Gadomska,J.: Terms of Immunoelectrophoretic Resolution of Blood Serum Proteins. Bromat. Chem. Toksykol. 5: 89-100, 1972.
2. Byczkowski,S., Gadomska,J.& Byczkowski,J.Z.: Application of Immunoelectophoresis to Toxicological Analysis. Acta Polon. Pharm. 29: 449-510, 1972.
3. Byczkowski,J.Z.& Gadomska,J.: The Comparison of Immunoelectrophoretical Patterns of Human and Rat Blood Serum Proteins. Zwierz. Laborator. 10: 28- 36, 1973.
4. Byczkowski,J,Z., Swierczynski,J.& Popinigis,J: The Effect of p,p'-DDT (Dicophane) and its Metabolites on ATPase Activity in Rat Liver Mitochondria. Arch. Toxicol. 31: 137-145, 1973.
5. Byczkowski,J.Z.: The Effect of p,p'-DDT (Dicophane) and its Main Metabolites on the Respiration of Rat Liver Mitochondria. Arch. Toxicol. 31: 137-145, 1973.
6. Zydowo,M., Wrzolkowa,T.& Byczkowski,J.Z.: Electron Microscopic studies on Myosin and AMP-Aminohydrolase-free Myosin. In Structure and Function of Normal and Diseased Muscle and Peripheral Nerve. Hausmanowa-Petrusewicz, J& Jedrzejowska, H.(eds), pp. 78, Polish Medical Publishers, Warsaw, 1974.
7. Byczkowski,J.Z.: Effects of p,p'-DDT and its Metabolites on Oxidative Processes in Animal and Plant Cells. Bromat. Chem. Toksykol. 7: 327-336, 1974.
8. Byczkowski,J.Z.: Effects of DDT in Vertebrates. Bromat. Chem. Toksykol. 9: 85-95, 1976.
9. Byczkowski,J.Z., Zychlinski,L., Stachowiak,M.& Byczkowski,S.: Effects of Manganese on Substrate Oxidation and Oxidative Phosphorylation in Rat Liver Mitochondria. Pol. J. Pharm. 28: 323-327, 1976.
10.Byczkowski,J.Z.& Korolkiewicz,K.Z.: Inhibition of Monoamine Oxidase Activity by Phenacetin and Salicylamide. Pharmacol. Res. Comm. 8: 477-483, 1976.
11.Byczkowski,J.Z.& Korolkiewicz,K.Z.: The Influence of Some Inhibitors of PGs Synthesis on Bioenergetics of Mitochondria. Naunyn-Schmiedeberg's Arch. Pharmacol. 249: R- 5, 1976.
12.Zychlinski,L., Stachowiak,M., Byczkowski,J.Z.& Cempel,M.: Effect of Intratracheal Administration of Manganese Dioxide on Liver and Brain Enzymes Activities in Rat. Bromat. Chem. Toksykol. 9: 307-313, 1976.
13.Byczkowski,J.Z.& Borysewicz,R: Action of Some Neurotropic Drugs and Cu2+ Cations on Mitochondrial Membrane Permeability. Gen. Pharmac. 7: 365-369, 1976.
14.Byczkowski,J.Z.: The Mode of Action of p,p'-DDT on Mammalian Mitochondria. Toxicology 6: 309-314, 1976.
15.Byczkowski,J.Z.: Relationship Between Structure of 1,1,1-Trichloro-2,2-Bis(p-chlorphenyl) Ethane Metabolites and Their Effects on Oxidative Phosphorylation. In: Bioenergetics and Mitochondria. Russanov,E.& Balevska,P.(eds), pp. 171-177, Publishing House of Bulgarian Academy of Sciences, Sofia, 1976.
16.Byczkowski,J.Z.& Korolkiewicz,K.Z.: The Sites of Action of Indomethacin in Rat Liver Mitochondria. Pharm. Res. Comm. 9: 259-268, 1977.
17.Byczkowski,J.Z.: Bioenergetics of Thermogenesis. Part I. Mechanisms of Heat Production on Body Level. Bromat. Chem. Toksykol. 10: 187-206, 1977.
18.Byczkowski,J.Z.: Basis of Pharmacological Treatment of Acute Poisonings. Terapia i Leki. 27: 339-349, 1977.
19.Byczkowski,J.Z.: Biochemical and Ultrastructural Changes in Biological Membranes Induced by p,p'-DDT (Chlorophenotanum) and its Metabolites. Pol. J. Pharmacol. Pharm. 29: 411-417, 1977.
20.Byczkowski,J.Z.: Bioenergetics of Thermogenesis. Part II. Action of Some Selected Compounds Stimulating the Heat Production on Body Level. Bromat. Chem. Toksykol. 10: 287-299, 1977.
21.Byczkowski,J.Z., Hac,E.E.M. & Korolkiewicz,Z.K.: Cu2+ and Salicylate Interaction with Energy Transformation in Mitochondria. Studia Biophys. (Berlin) 66: 189-199, 1977.
22.Byczkowski,J.Z.: Bioenergetics of Thermogenesis. Part III. Effects of Some Agents Inhibiting Heat Production in the Body with Particular Regards to DDT-Induced Hyperthermia. Bromat. Chem. Toksykol. 10: 413-430, 1977.
23.Byczkowski,J.Z.& Korolkiewicz,Z.K.: Inhibition of State 3 Respiration and Prostaglandin Beta-Oxidation in Rat Liver Mitochondria Treated with Some Neurotropic and Anti-Pyretic Drugs. Gen. Pharm. 9: 55-57, 1978.
24.Byczkowski,J.Z.: Bioenergetics of Thermogenesis: Effects of Some Neurotropic Drugs on Heat Production. Gen. Pharm. 9: 425-430, 1978.
25.Byczkowski,J.Z.& Tluczkiewicz,J.: Comparative Study of Respiratory Chain Inhibition by DDT and DDE in Mammalian and Plant Mitochondria. Bull. Environ. Contam. Toxicol. 20: 505-512, 1978.
26.Byczkowski,J.Z.& Hac,E.E.: Relationship Between Inhibition of Prostaglandin Beta- Oxidation and Deenergization of Mitochondrial Membranes. Acta Biol. Med. Germ. 37: 895-896, 1978.
27.Byczkowski,J.Z., Zychlinski,L.& Tluczkiewicz,J.: Interaction of Vanadate with Respiratory Chain of Rat Liver and Wheat Seedling Mitochondria. Int. J. Biochem. 10: 1007-1011, 1979.
28.Byczkowski,J.Z.& Borysewicz,R.: The Action of Chlorpromazine and Imipramine on Rat Brain Mitochondria. Gen. Pharm. 10: 369-372, 1979.
29.Byczkowski,J.Z.& Tluczkiewicz,J.: Mechanism of DDT and DDE Actions on Mitochondria Isolated from Rye and Wheat Seedlings, Bromat. Chem. Toksykol. 12: 345-349, 1979.
30.Byczkowski,J.Z., Salamon,W.,Harlos,J.P.& Porter,C.W.: Action of Bis(Guanylhydrazones) on Isolated Rat Liver Mitochondria. Biochem. Pharmacol. 30: 2851-2860, 1981.
31.Byczkowski,J.Z., Zychlinski,L.& Porter,C.W.: Potentiation of the Antimitochondrial and Antiproliferative Effects of Methylglyoxal-bis(Guanylhydrazone) [MGBG] by Phenethylbiguanide [DBI]. Cancer Res. 42: 3592-3595, 1982.
32.Byczkowski,J.Z., Zychlinski,L.& Porter,C.W.: Inhibition of the Bioenergetic Functions of Isolated Rat Liver Mitochondria by Polyamines. Biochem. Pharmacol. 31: 4045-4053, 1982.
33.Byczkowski,J.Z.: The Mode of Action of Chlorpromazine on Mitochondrial Membrane Permeability to K+. Gen. Pharm. 14: 413-417, 1983.
34.Byczkowski,J.Z.& Porter,C.W.: Interactions Between Bis(guanylhydrazones) and Polyamines in Isolated Mitochondria. Gen. Pharm. 14: 615-621, 1983.
35.Byczkowski,J.Z.& Sorenson,J.R.J.: Effects of Metal Compounds on Mitochondrial Function: A Review. Sci. Total Environ. 37: 133-162, 1984.
36.Byczkowski,J.Z.& Gessner,T.: Action of Xanthine-Xanthine Oxidase System on Microsomal Benzo(a)pyrene Metabolism In Vitro. Gen. Pharm. 18: 385-395, 1987.
37.Byczkowski,J.Z.& Gessner,T.: Effects of Superoxide Generated In Vitro on Glucuronidation of Benzo(a)pyrene Metabolites by Mouse Liver Microsomes. Int. J. Biochem. 19: 531-537, 1987.
38.Byczkowski,J.Z. & Gessner,T.: Asbestos-Catalyzed Oxidation of Benzo(a)pyrene by Superoxide-Peroxidized Microsomes. Bull. Environ. Contam. Toxicol. 39: 312-317, 1987.
39.Byczkowski,J.Z.& Gessner,T.: Interaction Between Vitamin K3 and Benzo(a)pyrene Metabolism in Uninduced Microsomes. Int. J. Biochem. 19: 1173-1179, 1987.
40.Gessner,T.& Byczkowski,J.Z.: A Simplified Method for Determination of Radioactive Metabolites of Benzo(a)pyrene Using HPLC with Radioactive Flow Detection. Progress HPLC. 3: 149-165, 1988.
41.Byczkowski,J.Z.& Gessner,T.: Biological Role of Superoxide Ion-Radical. Minireview. Int. J. Biochem. 20: 569-580, 1988.
42.Byczkowski,J.Z., Wan,B.& Kulkarni,A.P.: Vanadium-mediated Lipid Peroxidation in Microsomes from Human Term Placenta. Bull. Environ. Contam. Toxicol. 41: 696-703, 1988.
43.Byczkowski,J.Z.& Gessner,T.: Inhibition of the Redox Cycling of Vitamin K3 (Menadione) in Mouse Liver Microsomes. Int. J. Biochem. 20: 1073-1079, 1988.
44.Byczkowski,J.Z.& Gessner,T.: Effects of Inhibition of NADPH:Cytochrome P-450 Reductase on Benzo(a)pyrene Metabolism in Mouse Liver Microsomes. Int. J. Biochem. 21: 525-529, 1989.
45.Byczkowski,J.Z.& Kulkarni,A.P.: NADPH - dependent Drug Redox Cycling and Lipid Peroxidation in Microsomes from Human Term Placenta. Int. J. Biochem. 21: 183-190, 1989.
46.Byczkowski,J.Z. & Kulkarni,A.P.: Lipoxygenase-Catalyzed Epoxidation of Benzo(a) pyrene-7,8- dihydrodiol. Biochem. Biophys. Res. Comm. 159: 1190-1205, 1989.
47.Byczkowski,J.Z. & Kulkarni,A.P.: Lipid Peroxidation-Coupled Co-Oxygenation of Benzo(a)pyrene and Benzo(a)pyrene-7,8-dihydrodiol in Human Term Placental Microsomes. Placenta 11: 17-26, 1990.
48.Zychlinski,L.& Byczkowski,J.Z.: Inhibitory Effects of Vanadium Pentoxide on Respiration of Rat Liver Mitochondria. Arch. Environ. Contam. Toxicol. 19: 138-142, 1990.
49.Kulkarni,A.P., Mitra,A., Chaudhuri,J., Byczkowski,J.Z. & Richards,I.: Hydrogen peroxide: a potent activator of dioxygenase activity of soybean lipoxygenase. Biochem. Biophys. Res. Comm. 166: 417-423, 1990.
50.Byczkowski,J.Z. & Kulkarni,A.P.: Lipid Peroxidation and Benzo(a)pyrene Derivative Co-Oxygenation by Environmental Pollutants. Bull. Environ. Contam. Toxicol. 45: 633-640, 1990.
51.Byczkowski,J.Z., & Kulkarni A.P.: Activation of Benzo(a)pyrene-7,8-dihydrodiol in rat uterus: an in vitro study. J. Biochem. Toxicol. 5: 139-145, 1990.
52.Zychlinski,L., Byczkowski,J.Z. & Kulkarni, A.P.: Toxic Effects of Long-Term Intratracheal Administration of Vanadium Pentoxide in Rats. Arch. Environ. Contam. Toxicol. 20: 295-298, 1991.
53.Byczkowski,J.Z., Ramgoolie,P.J., & Kulkarni,A.P.: Proline hydroxylation by soybean lipoxygenase. Biochem. Internat. 25: 639-646, 1991.
54.Byczkowski,J.Z., & Kulkarni,A.P.: Linoleate-dependent co-oxygenation of benzo(a)pyrene and benzo(a)pyrene-7,8-dihydrodiol by rat cytosolic lipoxygenase. Xenobiotica 22: 609-618, 1992.
55.Byczkowski,J.Z., & Kulkarni,A.P.: Vanadium redox cycling, lipid peroxidation and co-oxygenation of benzo(a)pyrene-7,8-dihydrodiol. Biochem. Biophys. Acta 1125: 134-141, 1992.
56.Byczkowski,J.Z., Ramgoolie,P.J., & Kulkarni,A.P.: Some aspects of activation and inhibition of rat brain lipoxygenase. Int. J. Biochem. 24: 1691-1695, 1992.
57.Byczkowski,J.Z.: Lipid peroxidation and Benzo(a)pyrene cooxygenation. Advances in Polyunsaturated Fatty Acid Research (T.Yasagi, H.Nakamura, M.Soma, Eds.), Excerpta Medica, Amsterdam pp. 107-110, 1993.
58.Byczkowski,J.Z., Gearhart,J.M., & Fisher, J.W.:"Occupational" exposure of infants to toxic chemicals via breast milk. Nutrition 10: 43-48, 1994.
59.Byczkowski,J.Z., & Fisher,J.W.: Lactational transfer of tetrachloroethylene in rats. Risk Analysis 14: 339-349, 1994.
60.Byczkowski,J.Z., Kinkead,E.R., Leahy,H.F., Randall,G.M., & J.W. Fisher: Computer simulation of lactational transfer of tetrachloroethylene in rats using a physiologically based model. Toxicol. Appl. Pharmacol. 125: 228-236, 1994.
61.Joseph,P., Srinivasan,S.N., Byczkowski,J.Z. & Kulkarni,A.P.: Bioactivation of benzo(a) pyrene-7,8-dihydrodiol catalyzed by lipoxygenase purified from human term placenta and conceptal tissues. Reprod. Toxicol. 8: 307-313, 1994.
62.Byczkowski,J.Z., & Fisher,J.W.: A computer program linking physiologically based pharmacokinetic model with cancer risk assessment for breast-fed infants. Computer Meth. Progr. Biomed. 46: 155-163, 1995.
63.Byczkowski,J.Z.: Linked PBPK model and cancer risk assessment for breast-fed infants. Drug Inf. J. 30: 401-412, 1996.
64.Byczkowski,J.Z., & Channel,S.R.: Chemically-induced oxidative stress and tumorigenesis: effects on signal transduction and cell proliferation. Toxic Subst. Mechan. 15: 101-128, 1996.
65.Byczkowski,J.Z., Channel,S.R., Pravecek,T.L., & Miller,C.R.: Mathematical model for chemically induced lipid peroxidation in precision-cut liver slices: computer simulation and experimental calibration. Computer Meth. Progr. Biomed. 50: 73-84, 1996.
66.Yu,K.O., Tillitt,D.E., Byczkowski,J.Z., Burton Jr., G.A., Channel, S.R., Drerup, J.M., Flemming, C.D., & Fisher, J.: In vivo/in vitro comparison of the pharmacokinetics and pharmacodynamics of 3,3',4,4'-tetrachlorobiphenyl (PCB77). Toxicol. Appl. Pharmacol. 141: 434-438, 1996.
67. Lipscomb,J.C., Fisher,J.W., Confer,P.D., & Byczkowski,J.Z.: In vitro to in vivo extrapolation for trichloroethylene metabolism in humans. Toxicol. Appl. Pharmacol. 152:376-387, 1998.
68. Byczkowski,J. Z., Channel,S. R. & Miller,C. R.: A biologically based pharmacodynamic model for lipid peroxidation stimulated by trichloroethylene in vitro. J. Biochem. Molecular Toxicol. 13: 205-214, 1999.
69. Lipscomb,J.C., Byczkowski,J.Z., and Harvey,T.: Physiologically based pharmacokinetic modeling of the lactational transfer of methylmercury. In: Metal Ions in Biolgy and Medicine (Centeno,J.A., Collery,P., Vernet,G., Finkelman,R.B., Gibb,H., Etienne,J.C., Eds.) Vol. 6, pp. 730-732, John Libbey Eurotext, Paris 2000.
70. Dorman, D.C., Allen, S.L., Byczkowski, J.Z., Claudio, L., Fisher, J.W., Harry, G.J., Li, A.A., Makris, S.L., Padilla, S., Sultatos, L.G., and Mileson, B.E.: Methods to Identify and Characterize Developmental Neurotoxicity for Human Health Risk Assessment: III. Pharmacokinetic and Pharmacodynamic Considerations. Environmental Health Perspectives. 109 (Suppl 1) 101-111, 2001.
71. Byczkowski, J.Z., and Lipscomb, J.C.: Physiologically Based Pharmacokinetic Modeling of the Lactational Transfer of Methylmercury. Risk Anal. 21: 869-882, 2001.
72. Byczkowski, J.Z.: Methyl Mercury Toxicity: Pharmacokinetics And Toxicodynamic Aspects. In: Reviews in Food and Nutrition Toxicity, Vol.3: Toxic and Pathological Aspects (Preedy,V.R. and Watson,R., Eds.). CRC Press LLC, Boca Raton, FL, 2005.
***
* TECHNICAL REPORTS:
1. Byczkowski,J.Z.: A Procedure for Isolation of Stable Mouse Liver Mitochondria and Reagents for their Investigation. Roswell Park Memorial Institute, Buffalo, N.Y. 1979.
2. Barton, H.A., Byczkowski, J.Z., Channel, S.R., Jarnot, B.M., Lipscomb, J.C., & Williams, R.J.: Trichloroethylene: metabolism and other biological determinants of mouse liver tumors. Technical Report AL/OE-TR-194-0135, 1994.
3. Williams,R.J., Creech,J.R., Black,R.K., Neurath,S.K., Jepson,G.W., & Byczkowski,J.Z.: Gas uptake kinetics of bromotrifluoromethane (Halon 1301) and its proposed replacement iodotrifluoromethane (CF3I). Technical Report AL/OE-TR-1994- 0068, 1994.
4. Byczkowski,J.Z., & Fisher,J.W.: Tetrachloroethylene: exposure and risk assessment in breast-fed infants. 1993 Toxic Hazards Res. Unit Ann. Rep. No. AL/OE-TR-1994-0119, pp. 67-81, 1994.
5. Byczkowski,J.Z., & Fisher,J.W.: Application of physiologically based pharmacokinetic model to cancer risk assessment for breast-fed infants. 1994 Toxic Hazards Res. Unit Ann. Rep. No. AL/OE-TR-1995-0135, 1995.
6. Byczkowski,J.Z., Channel,S.R., & Pravecek,T.L.: Development and experimental calibration of the mathematical model of lipid peroxidation in mouse liver slices. Technical Report AL/OE- TR-0179, 1995.
7. Byczkowski,J.Z., Seckel,C.S., Black,R.K., Creech,J.R. & Garrity,B.L.: Development and validation of a physiologically based pharmacokinetic model of chloral hydrate and its main metabolites. Technical Report AL/OE-TR-0178, 1995.
8. Byczkowski,J.Z., & Flemming,C.D.: Mathematical modeling of oxidative stress in vitro. 1995 Toxic Hazards Res. Unit Ann. Rep. No. AL/OE-TR-1996-0132, 1996.
9. Byczkowski,J.Z., & Seckel,C.S.: Development of physiologically based pharmacodynamic model for ethane exhalation. 1995 Toxic Hazards Res. Unit Ann. Rep No. AL/OE-TR-1996- 0132, 1996.
10.Byczkowski, J.Z., & Kulkarni, A.P.: Pro-oxidant biological effects of inorganic components of petroleum: vanadium and oxidative stress. Technical Report AL/OE-TR-0126, 1996.
11.Byczkowski,J.Z., Flemming,C.D., Curran,M.A., Miller,C.R., Schmidt,W.J., Moghaddam, A.P., Channel, S.R.: Physiologically based pharmacodynamic modeling of chemically induced oxidative stress. Technical Report AL/OE-TR-1997- 0130.
12. Byczkowski,J.Z., Miller,C.R., Curran,M.A., Schmidt,W.J., Channel,S.R.: Experimental calibration of biologically based dose-response model for lipid peroxidation induced by trichloroethylene. 1996 Toxic Hazards Res. Unit Ann. Rep No. AL/OE TR 1997- 0124, 1997.
13. Byczkowski,J.Z., Curran,M.A., Miller,C.R., Schmidt,W.J.: Dose-response characteristics of lipid peroxidation induced by bromotrichloromethane in B6C3F1 mice. 1996 Toxic Hazards Res. Unit Ann. Rep No. AL/OE TR 1997- 0124, 1997.
14. Byczkowski, J.Z. & Lipscomb, J.C.: PBPK modeling of oxidative metabolism of TCE in humans: dissection of experimental error and interindividual variability. 1997 Toxic Hazards Res. Ann. Rep. No. AFRL-HE-WP-TR- 1998-0135, 1998.
15. Byczkowski, J.Z.: Interlinked pharmacodynamic model for TCE induced oxidative stress. 1997 Toxic Hazards Res. Ann. Rep. No. AFRL-HE-WP-TR-1998-0135, 1998.
16. Byczkowski,J.Z.: Interlinked pharmacodynamic model for TCE induced oxidative stress. 1997 Toxic Hazards Res. Ann. Rep. No. AFRL-HE-WP-TR-1998-0135, 1998.
17. TN & A, Inc. Draft Risk Assessment Issue Paper for: Evaluation of the Provisional Toxicity Values, Cancer and Non-Cancer, of DINP (CASRN. 28553-12-0).
18. TN & A, Inc. Draft Risk Assessment Issue Paper for: Limitations and Pitfalls of Route-to-Route Extrapolations.
19. TN & A, Inc. Draft Risk Assessment Issue Paper for: Results of Review of Revised Breast Milk Pathway Model.
20. TN & A, Inc. Draft Risk Assessment Issue Paper for: Derivation of a Provisional Subchronic RfC for Cadmium (CASRN 7440-43-9).
21. TN & A, Inc. Draft Risk Assessment Issue Paper for: Toxicity Values for COPCs.
22. TN & A, Inc. Draft Risk Assessment Issue Paper for: Evaluation of the Provisional Toxicity Values, Cancer and Non-Cancer, of Oleic Acid (CASRN. 112-80-1).
23. TN & A, Inc. Draft Risk Assessment Issue Paper for: An Updated Systemic Toxicity Evaluation of n-Hexane (CASRN. 110-54-3).
24. TN & A, Inc. Draft Risk Assessment Issue Paper for: Derivation of Provisional Oral Chronic RfD and Subchronic RfDs for 1,1,1-Trichloroethane (CASRN. 71-55-6).
25. TN & A, Inc. Draft Risk Assessment Issue Paper for: Derivation of Provisional Chronic and Subchronic RfCs for 1,1,1-Trichloroethane (CASRN. 71-55-6).
26. TN & A, Inc. Draft Risk Assessment Issue Paper for: Deriving a Provisional Subchronic Inhalation RfC for Toluene (CASRN 108-88-3) Using Physiologically-Based Pharmacokinetic Modeling.
27. TN & A, Inc. Draft Risk Assessment Issue Paper for: Revised Update Quantifying the Uncertainty Bounding the Inhalation Unit Risk for Tetrachloroethylene (CASRN 127-18-4).
28. TN & A, Inc. Draft Risk Assessment Issue Paper for: Application of Physiologically-Based Pharmacokinetics to Assess the Transfer of Methylmercury to the Developing Human.
29. TN&A, Inc. Draft Risk Assessment Issue Paper for: Human Health Risk Associated with Indirect Exposure to Combustion Emissions: (1) Modeling of the Transfer of Air-Borne Contaminants Through the Food Chain and (2) Notes on the Appropriateness of Including VOCs in the Assessment of Risk from Indirect Exposure.
30. TN&A, Inc. Draft Risk Assessment Issue Paper for: Modeling of Soil Concentration Algorithms for Assessing Indirect Exposure Pathways.
31. Versar, Inc. Review Draft NCEA: Issue Area 2 - Relative Tissue Distribution and Excretion Capacities in Infants, Children and the Unborn. In: Exploration of Perinatal Pharmacokinetic Issues.
32. Versar, Inc. Review Draft NCEA: Issue Area 4 - Transfer from Plasma to Milk. In: Exploration of Perinatal Pharmacokinetic Issues.
33. Versar, Inc. Review Draft NCEA: Appendix - Pharmacokinetics and Computer-Aided Quantitative Modeling in Developmental Toxicology. In: Exploration of Perinatal Pharmacokinetic Issues.
34. U.S. Environmental Protection Agency (2002): Final Report "EXPLORATION OF PERINATAL PHARMACOKINETIC ISSUES", EPA/630/R-01/004, May 10, 2001. Download
35. U.S. Environmental Protection Agency (2002): Summary Report of the Technical Peer Review Workshop on the Draft Document Entitled "A review of the Reference Dose and Reference Concentration Process". Risk Assessment Forum, U.S. EPA, Washington, DC. EPA/630/R-03/001 "Review by Janusz Byczkowski, Independent Consultant" August 7, 2002. Fig. 1, Pages F3 - 8 Download
36. Ohio EPA Division of Emergency and Remedial Response (2002): TECHNICAL DECISION COMPENDIUM. Title: Application of Bioavailability in the Assessment of Human Health Hazards and Cancer Risk. 26 March 2002 Download
37. U.S. Environmental Protection Agency (2005): Panel Peer Review of the Draft NCEA Document "Approaches for the Application of Physiologically Based Pharmacokinetic Models and Supporting Data in Risk Assessment" Arlington, VA, November 10-11, 2005. Download
38. Ohio EPA Division of Emergency and Remedial Response (2004): TECHNICAL DECISION COMPENDIUM. Title: Assessing Compounds without Formal Toxicity Values Available for Use in Human Health Risk Assessment. 4 April 2004 (updated August 2005) Download
39. Ohio EPA Division of Emergency and Remedial Response (2006): TECHNICAL DECISION COMPENDIUM. Title: Perchlorate Screening Values. March 15, 2006 Download
***
* BOOK CHAPTERS AND INVITED REVIEW ARTICLES:
1. Kulkarni,A.P., & Byczkowski,J.Z.: Hepatotoxicity. In: Introduction to Biochemical Toxicology, Chapter 20 (Hodgson,E., Levi,P.E., Ed.), pp. 459 - 490, Appleton and Lange, Norwalk, CT, 1993.
2. Byczkowski,J.Z. & Kulkarni,A.P.: Oxidative stress and asbestos. In: Environmental Oxidants, Chapter 15 (Advances in Environmental Sciences and Technology, Nriagu, J.O., Ed), pp. 459 - 474, J.Wiley & Sons, New York, 1994.
3. Kulkarni,A.P., & Byczkowski,J.Z.: Effects of transition metals on biological oxidations. In: Environmental Oxidants, Chapter 16 (Advances in Environmental Sciences and Technology, Nriagu,J.O. Ed), pp. 475 - 496, J.Wiley & Sons, New York, 1994.
4. Byczkowski,J.Z., & Kulkarni,A.P.: Oxidative stress and pro-oxidant biological effects of vanadium. In: Vanadium in the Environment. Part 2: Health Effects, Chapter 12 (Nriagu,J.O. Ed), pp. 235 - 264, J.Wiley & Sons, New York, 1997.
5. Byczkowski,J.Z.: Pharmacokinetic/Dynamic Modeling. In: The Standard Handbook of Environmental Science, Health and Technology, Chapter 8.6 (Lehr,J., Ed), McGraw-Hill, New York, 2000.
6. Byczkowski, J.Z.: Pharmacokinetic Approach and Mathematical Modeling. In: Handbook of Elemental Speciation II, Chapter 5 (Cornelis, R., Ed.), John Wiley & Sons, Inc., London, 2005.
***
* SHORT COMMUNICATIONS AND ABSTRACTS:
1. Byczkowski,S., Gadomska,J. & Byczkowski,J.Z.: Preliminary Investigations on Adaptation of Immunoelectrophoresis to Toxicological Analysis. 9th Scientific Congress of The Polish Pharmaceutical Society, Abstr. p.51, Lodz, 1970.
2. Byczkowski,J.Z., Swierczynski,J. & Zydowo,M.: Effects of p,p'-DDT and its Main Metabolites on Oxidative Processes in Rat Liver Mitochondria. 11th Meeting of The Polish Biochemical Society, Abst. p.35, Bialystok, 1973.
3. Byczkowski,J.Z.& Zydowo,M.: Isolation and Some Properties of AMP Deaminase from Bovine Heart. 12th Meeting of The Polish Biochemical Society, Abst. p.172, Warszawa, 1974.
4. Stachowiak,M., Byczkowski,J.Z.& Zychlinski,L.: Action of Manganese on Some Activities of Rat Brain and Liver Mitochondrial Fractions. 13th Meeting of The Polish Biochemical Society, Abst. p.176, Torun, 1975.
5. Byczkowski,J.Z.: Effects of p,p'-DDT and its Main Metabolites on Oxidative Phosphorylation Process in Rat liver Mitochondria. 13th Meeting of The Polish Biochemical Society, Abst. p. 172, Torun, 1975.
6. Byczkowski,J.Z.: Effects of p,p'-DDT on Energy Conservation in Rats Mitochondria. 5th Congress of The Polish Pharmacological Society, Abst. p. 190, Szczecin, 1975.
7. Byczkowski,J.Z.: Relationship Between Structure of 1,1,1-Trichloro-2,2-bis- p-chloro- phenyl) Ethane Metabolites and Their Effects on Oxidative Phosphorylation. 5th International Colloquium and School on Bioenergetics and Mitochondria, Abst. p.25, Varna/Bulgaria, 1975.
8. Byczkowski,J.Z.: Action of p,p'-DDT and its Main Metabolites on Electron Transport and Energy Conservation Process in Rat Mitochondria. Proc. of the Scientific Soc. of Gdansk, p. 245-246, Gdansk, 1976.
9. Hac,E.& Byczkowski,J.Z.: Effects of Cu2+ and Salicylate on Rat Liver Mitochondria. 14th Meeting of The Polish Biochemical Society, Abst. p. 41, Lublin, 1976.
10.Borysewicz,R.& Byczkowski,J.Z.: Action of Some Neurotropic Drugs and Cu2+ on Mitochondrial Membrane Permeability. 14th Meeting of The Polish Biochemical Society, Abst. p. 51, Lublin, 1976.
11.Byczkowski,J.Z.& Korolkiewicz,Z.: Inhibition of Prostaglandin Oxidation in Rat Liver Mitochondria by Some Drugs. 14th Meeting of The Polish Biochemical Society, Abst. p. 121, Lublin, 1976.
12.Byczkowski,J.Z.: Effects of Some Neurotropic Drugs on Mitochondrial Membrane Permeability and Inhibition of State 3 Respiration. 7th International Colloquium on Bioenergetics and Mitochondria, Abst. p. A13, Gdansk, 1977.
13.Hac,E.& Byczkowski,J.Z.: Action of Indomethacin and Cu2+ on Passive Mitochondrial Membrane Permeability to K+ and Na+. 15th Meeting of The Polish Biochemical Society, Abst. p.98, Gdansk, 1977.
14.Byczkowski, J.Z.: Action of Drugs that Inhibit Thermogenesis on Bioenergetics of Mitochondria. 15th Meeting of The Polish Biochemical Society, Abst. p. 99, Gdansk, 1977.
15.Byczkowski,J.Z.: Interaction Between p,p'-DDOH and Some Neurotropic Drugs at the Level of Biological Membranes. 15th Meeting of The Polish Biochemical Society, Abst. p. 120, Gdansk, 1977.
16.Tluczkiewicz,J.& Byczkowski,J.Z.: Action of p,p'-DDT and p,p'-DDE on Respiratory Activity of Mitochondria from Wheat and Rye Seedlings and Rat Liver. 15th Meeting of The Polish Biochemical Society, Abst. p. 123, Gdansk, 1977.
17.Borysewicz,R.& Byczkowski,J.Z.: Action of Some Neurotropic Drugs on Respiratory Activity of Rat Brain Mitochondrial Fraction. 15th meeting of The Polish Biochemical Society, Abst. p. 128, Gdansk, 1977.
18.Byczkowski,J.Z.& Hac,E.: Relationship Between Inhibition of Prostaglandin Beta-Oxidation and State 3 Respiration in Mitochondria. 2nd International Symposium on Prostaglandins and Cardiovascular System. Abst. p. 38, Halle/Saale, 1977.
19.Byczkowski,J.Z.& Korolkiewicz,Z.K.: The Action of Drugs Affecting Thermogenesis on Mitochondrial Membranes. 6th Congress of The Polish Pharmacological Society, Abst. p. 28, Katowice, 1977.
20.Borysewicz,R., Byczkowski,J.Z.& Korolkiewicz,Z.K.: Mode of Action of Some Neurotropic Drugs on Biomembranes. 6th Congress of The Polish Pharmacological Society, Abst. p. 316, Katowice, 1977.
21.Byczkowski,J.Z.: Pharmacological Control of Heat Production in Peripheral Tissue. 12th Fedn. Europ. Biochem. Soc. Meeting, Abst. p. 1859, Dresden, 1978.
22.Zychlinski,L.& Byczkowski,J.Z.: Oxido-Reduction Properties of Vanadium at Rat Liver Mitochondria. 12th Fedn. Europ. Biochem. Soc. Meeting, Abst. p. 1720, Dresden, 1978.
23.Byczkowski,J.Z., Tluczkiewicz,J.& Zychlinski,L.: Donor-Acceptor Action of Vanadium on Grain Mitochondria. 16th Meeting of The Polish Biochemical Society, Abst. p.81, Lodz, 1978.
24.Byczkowski,J.Z.: Modification of Mitochondrial Membranes Permeability by Neurotropic Drugs. 16th Meeting of the Polish Biochemical Society, Abst. p. 199, Lodz, 1978.
25.Byczkowski,J.Z.& Zychlinski,L.: Interaction of Vanadium with Electron Transport Chain in Rat Liver Mitochondria In Vitro. 16th Meeting of The Polish Biochemical Society, Abst. p. 62, Lodz, 1978.
26.Byczkowski,J.Z.: Action of Some Neurotropic and Anti - pyretic Drugs on Rat Liver and Brain Mitochondria. 18th International Colloquium on Bioenergetics and Mitochondria, Abst. p. 49, Smolenice Castle, Czechoslovakia, 1979.
27.Byczkowski,J.Z.& Porter,C.W.: Effects of Methylglyoxal-bis(guanylhydrazone) [MGBG] on Isolated Rat Liver Mitochondria. Dept. of Exp. Therap. and Grace Cancer Drug Ctr. Progress report, p. 91, RPMI, Buffalo, N.Y., 1980.
28.Byczkowski,J.Z.& Porter,C.W.: Interaction Between Antiproliferative Bis (guanylhydrazones) and Phenethylbiguanide in Isolated Rat Liver Mitochondria. Dept. of Exp. Therap. and Grace Cancer Drug Ctr. Progress Report, p. 92, Buffalo, N.Y., 1980.
29.Byczkowski,J.Z., Salamon,W.& Porter,C.W.: The Action of Bis(guanylhydrazones) on Isolated Rat Liver Mitochondria. Dept. of Exp. Therap. and Grace Cancer Drug Ctr. Progress Report, p. 92, RPMI, Buffalo, N.Y., 1980.
30.Byczkowski,J.Z.& Porter,C.W.: Modulating Effects of Polyamines on Bioenergetic Functions of Isolated Mitochondria. Dept. of Exp. Therap. and Grace Cancer Drug Ctr. Progress Report, p. 83, RPMI, Buffalo, N.Y., 1981.
31.Byczkowski,J.Z.& Porter,C.W.: Neutralization of Mitochondrial Surface Potential by Polyamines. 18th Meeting of The Polish Biochemical Society, Abst. p. 312, Wroclaw, 1981.
32.Byczkowski,J.Z.& Porter,C.W.: Biochemical Consequences of Surface Potential Neutralization in Mitochondria. Proc. 6th School on Biophysics of Membrane transport, p. 370, Poland, 1981.
33.Byczkowski,J.Z.& Porter,C.W.: Interactions Between Bis(guanylhydrazones) and Polyamines in Isolated Mitochondria. Dept. of Exp. Therap. and Grace Cancer Drug Ctr. Progress Report, p. 81, RPMI, Buffalo, N.Y., 1982.
34.Byczkowski,J.Z., Zychlinski,L. & Porter,C.W.: Potentiation of the Antimitochondrial and Antiproliferative Effects of Bis(guanylhydrazones) by Phenethylbiguanide. Dept. of Exp. Therap. and Grace Cancer Drug Ctr. Progress Report, p. 82, RPMI, Buffalo, N.Y., 1982.
35.Byczkowski,J.Z., Zychlinski,L.& Porter,C.W.: Inhibition of the Bioenergetic Functions of Isolated Rat Liver Mitochondria by Polyamines. Dept. of Exp. Therap. and Grace Cancer Drug Ctr. Progress Report, p. 82, RPMI, Buffalo, N.Y., 1982.
36.Byczkowski,J.Z.& Gessner,T.: Modification of Microsomal Metabolism of Benzo(a)pyrene [BaP] by Superoxide generated In Vitro. 70th Annual Meeting FASEB, St.Louis, Mo., Fed. Proc. 45: 3146, 1986.
37.Byczkowski,J.Z.: Surface Potential Neutralization in Mitochondrial Membranes by Cationic Drugs and Inorganic Cations. Proc. International Symp. Molecular Mechanisms of Membrane Fusion. p. 17 (42), SUNY at Buffalo, N.Y., 1987.
38.Byczkowski, J.Z. & Gessner, T.: Superoxide-Induced Microsomal Lipid Peroxidation and Benzo(a)pyrene Metabolism In Vitro. 4th International Congress on Oxygen Radicals, Contributed Abstracts, Tuesday, p. 47-50, UC San Diego, Calif. 1987.
39.Gessner,T.& Byczkowski,J.Z.: Effect of Vitamin K3 on Metabolism of Benzo(a)pyrene [BP]. Proc. 10th International Congress Pharmacol., p. O128, Sidney, Australia, 1987.
40.Gessner,T.& Byczkowski,J.Z.: Effect of Antioxidants and Naturally Occurring Quinones on Reduction of Menadione (Vitamin K3) and its Semiquinone Recycling. Proc. Symposium Drugs and the Liver, St. Vincent's Hospital, Melbourne, Australia, 1987.
41.Byczkowski,J.Z. & Kulkarni,A.P.: Co-Oxygenation as Alternative Pathway to Cytochrome P-450 for Benzo(a)pyrene Activation in Human Term Placental Microsomes. 8th Annual Meeting of the Society of Toxicology, Atlanta GA, Toxicologist 9: 92 (367) 1989.
42.Kulkarni,A.P. & Byczkowski,J.Z.: Biotransformation of Benzo(a)pyrene-7,8-diol in Rat Uterus In Vitro. 28th Annual Meeting of the Society of Toxicology, Atlanta GA, Toxicologist 9: 92 (368) 1989.
43.Zychlinski,L. & Byczkowski,J.Z.: Effects of Intratracheal V2O5 Administration on Rat Liver Mitochondria. 28th Annual Meeting of the Society of Toxicology, Atlanta GA, Toxicologist 9: 132 (528) 1989.
44.Kulkarni,A.P. & Byczkowski,J.Z.: Rat lung lipoxygenase-catalyzed epoxidation of benzo(a)pyrene-7,8-dihydrodiol. 29th Annual Meeting of the Society of Toxicology, Miami FL, Toxicologist 10: 171 (682) 1990.
45.Byczkowski,J.Z. & Kulkarni,A.P.: Peroxidation of linoleic acid by environmental pollutants: hydrated SO2, reduced vanadium, and asbestos. 29th Annual Meeting of the Society of Toxicology, Miami FL, Toxicologist 10: 172 (685) 1990.
46.Byczkowski,J.Z. & Kulkarni,A.P.: Vanadium induces co-oxygenation of benzo(a)pyrene and its diol in human term placental microsomes. 30th Annual Meeting of the Society of Toxicology, Dallas TX, Toxicologist 11: 46 (86) 1991.
47.Kulkarni,A.P., Naidu,A., Naidu,A., Ramgoolie,P.J. & Byczkowski,J.Z.: Rat brain lipoxygenase: hydroperoxidase activity and effects of hydroperoxides and monoamines on dioxygenase. 30th Annual Meeting of the Society of Toxicology, Dallas TX, Toxicologist 11: 216(800) 1991.
48.Kulkarni,A.P., Joseph,P. & Byczkowski,J.Z.: Effects of phenylbutazone and amino acids on benzo(a)pyrene-7,8-dihydrodiol cooxygenation by partially purified placental peroxidase. 31th Annual Meeting of the Society of Toxicology, Seattle WA, Toxicologist 12: 74 (197) 1992.
49.Byczkowski,J.Z., Ramgoolie,P.J. & Kulkarni,A.P.: Lipoxygenase hydroxylates proline. 31th Annual Meeting of the Society of Toxicology, Seattle WA, Toxicologist 12: 170 (604) 1992.
50.Byczkowski,J.Z.: Lipid peroxidation and benzo(a)pyrene cooxygenation. 5th Scientific Meeting of the Society for Research on Polyunsatureted Fatty Acids, Tokyo, Japan, Program and Abstract P1-2 (49) 1992.
51.Byczkowski,J.Z., Kinkead,E.R., Greene,R.J., Bankston,L.A., & Fisher,J.W.: Physiologically-based modeling of the lactational transfer of tetrachloroethylene. 32nd Annual Meeting of the Society of Toxicology, New Orleans, LA, Toxicologist 13: 354 (1385) 1993.
52.Joseph,P., Srinivasan,N.S., Byczkowski,J.Z., & Kulkarni,A.P.: Lipoxygenase mediated bioactivation of benzo(a)pyrene-7,8-dihydrodiol in human placenta. 32nd Annual Meeting of the Society of Toxicology, New Orleans, LA, Toxicologist 13: 60 (133) 1993.
53.Byczkowski,J.Z., & Fisher,J.W.: Lactational transfer of tetrachloroethylene in rats. Conference on the Risk Assessment Paradigm After Ten Years: Policy and Practice Then, Now, and in the Future. WPAFB Dayton, OH., Biographies and Papers EPA/630/R-93-039 March 1993.
54.Byczkowski,J.Z.: Lipid peroxidation and benzo(a)pyrene cooxygenation. Nutrition 9: 88, 1993.
55.Byczkowski,J.Z., & Fisher,J.W.: Quantitative Approach to assess risk from lactational transfer of tetrachloroethylene to breast-fed infants. Society for Risk Analysis Annual Meeting, Savannah, GA, Program and Abstracts E-10, 1993.
56.Byczkowski,J.Z., & Fisher,J.W.: Tetrachloroethylene exposure assessment of breast-fed infants. 33rd Annual Meeting of the Society of Toxicology, Dallas, TX, Toxicologist 14: 86 (45) 1994.
57.Byczkowski,J.Z.: Linked PBPK model and cancer risk assessment for breast-fed infants. Drug Information Association 30th Annual Meeting, Washington, DC, Abstracts Presentations, CM/PH, p. 69 (1994).
58.Das,S., Byczkowski,J.Z., & Fisher,J.W.: Probability analysis of TCE cancer bioassay data in the B6C3F1 mice using PBPK/PBPD modeling: a conceptual framework. Society for Risk Analysis Annual Meeting, Baltimore, MD, Final Program Abstracts P1-20, 1994.
59.Byczkowski,J.Z., Pravecek,T., & Channel,S.: Computer simulations of lipid peroxidation in precision cut mouse liver slices and experimental calibration of the mathematical model. 34th Annual Meeting of the Society of Toxicology, Baltimore, MD, Toxicologist 15: 281 (1504) 1995.
60.Seckel,C.S., Creech,J.R., Garrity,B.L., Black,R.K., & Byczkowski,J.Z.: Tissue solubility and kinetics for metabolites of trichloroethylene -chloral and trichloroethanol. 34th Annual Meeting of the Society of Toxicology, Baltimore, MD, Toxicologist 15: 198 (1059) 1995.
61.Byczkowski,J.Z., & Fisher,J.W.: Cancer risk assessment for breast-fed infants: a PBPK model. Conference on Risk Assessment Issues for Sensitive Human Populations, Wright Patterson AFB, OH. Registration and Abstract Booklet, p. 70, 1995.
62.Byczkowski,J.Z., Pravecek,T., & Channel,S.: Computer simulations of lipid peroxidation in precision cut mouse liver slices and experimental calibration of the mathematical model. Conference on Risk Assessment Issues for Sensitive Human Populations, Wright Patterson AFB, OH. Registration and Abstract Booklet, p. 70, 1995.
63.Seckel,C.S., Creech,J.R., Garrity,B.L., Black,R.K., & Byczkowski,J.Z.: Tissue solubility and kinetics for metabolites of trichloroethylene - chloral and trichloroethanol. Conference on Risk Assessment Issues for Sensitive Human Populations, Wright Patterson AFB, OH. Registration and Abstract Booklet, p. 91, 1995.
64.Byczkowski,J.Z., & Fisher,J.W.: Computer simulation of tetrachloroethylene exposure and cancer risk assessment for breast-fed infants. 104 Annual Meeting of the Ohio Acad. Sci., Westerville, OH. Oh. J. Sci. 95, A-47, 1995.
65.Byczkowski,J.Z.,& Flemming,C.D.: Computer-aided dose-response characteristics of chemically initiated oxidative stress in vitro. 35th Annual Meeting of the Society of Toxicology, Anaheim, CA. Toxicologist 30: 240 (1227) 1996.
66.Yu,K.O., Byczkowski, J.Z., Drerup,J.M., McCafferty,J.D., & Fisher,J.W.: Pharmacokinetics and pharmacodynamics of 3,3',4,4'-tetrachlorobiphenyl in the rats: PBPK model development. 35th Annual Meeting of the Society of Toxicology, Anaheim, CA. Toxicologist 30: 247 (1266) 1996.
67.Seckel,C.S, & Byczkowski,J.Z.: Experimental parameters to support a pharmacodynamic model for ethane exhalation. 35th Annual Meeting of the Society of Toxicology, Anaheim, CA. Toxicologist 30: 244 (1247) 1996.
68.Steel-Goodwin,L., Carmichael,A.J., Schmidt,W.W., Miller,C., & Byczkowski, J.Z.: Quantitation of free radicals in B6C3F1 mouse liver slices on exposure to four chemical carcinogens: an EPR/spin trapping study. 35th Annual Meeting of the Society of Toxicology, Anaheim, CA. Toxicologist 30: 243 (1246) 1996.
69.Byczkowski,J.Z., & Flemming,C.D.: A computer program for dose-response description of chemically induced oxidative stress. 105 Annual Meeting of the Ohio Acad. Sci., Canton, OH, 1996. Oh. J. Sci. 96: A-16(M) 1996.
70.Byczkowski,J.Z., & Flemming,C.D.: Computer-aided description of chemically initiated oxidative stress in vitro. Conference on Advances in Toxicology and Applications to Risk Assessment. WPAFB, OH, 1996. Abstract Booklet, pp. 73.
71.Steel-Goodwin,L.,Carmichael,A.J., Schmidt,W.W., Miller,C., & Byczkowski, J.Z.: Quantitation of free radicals in B6C3F1 mouse liver slices on exposure to four chemical carcinogens: an EPR/spin trapping study. Conference on Advances in Toxicology and Applications to Risk Assessment. WPAFB, OH, 1996. Abstract Booklet, pp. 94.
72.Seckel,C.S, & Byczkowski,J.Z.: Experimental parameters to support a pharmacodynamic model for ethane exhalation. Conference on Advances in Toxicology and Applications to Risk Assessment. WPAFB, OH, 1996. Abstract Booklet, pp. 91.
73.Yu,K.O., Byczkowski,J.Z., Drerup,J.M., McCafferty,J.D., & Fisher,J.W.: Pharmacokinetics and pharmacodynamics of 3,3',4,4'-tetrachlorobiphenyl in the rats: PBPK model development. Conference on Advances in Toxicology and Applications to Risk Assessment. WPAFB, OH, 1996. Abstract Booklet, pp. 99.
74.Byczkowski,J.Z., & Flemming,C.D.: Mathematical modeling of oxidative stress in vitro. American Chemical Soc. Mid-West Regional Meeting, Dayton, OH, 1996, Chemistry in the 90's and Beyond, Abs. 72.
75.Byczkowski,J.Z., Pravecek,T., & Channel,S.: Computer simulations of lipid peroxidation in precision cut mouse liver slices and experimental calibration of the mathematical model. American Chemical Soc. Mid-West Regional Meeting, Dayton, OH, 1996, Chemistry in the 90's and Beyond, Abs. 73.
76.Byczkowski,J.Z., & Seckel,C.S.: Development of physiologically based pharmacodynamic model for ethane exhalation. American Chemical Soc. Mid-West Regional Meeting, Dayton, OH, 1996, Chemistry in the 90's and Beyond, Abs. 74.
77.Steel-Goodwin, L., Schmidt, W.W., Miller, C., Byczkowski, J.Z., & Carmichael, A.J.: Quantitation of free radicals in B6C3F1 mouse liver slices on exposure to four chemical carcinogens: an ESR/spin trapping study. American Chemical Soc. Mid-West Regional Meeting, Dayton, OH, 1996, Chemistry in the 90's and Beyond, Abs. 68.
78.Byczkowski, J.Z., Flemming,J.Z., Miller,C.D., Schmidt,W.J., & Seckel,C.S.: Development and experimental calibration of biologically based dose-response model for oxidative stress. Society for Risk Analysis Annual Meeting, New Orleans, LA, 1996, Final Program F1.03, p. 89 (1996).
79.Byczkowski, J.Z., Schmidt, W.J., Curran, M.A., Moghaddam, A.P., Seckel, C.S.: Development and experimental calibration of physiologically based pharmacodynamic model for CCl4 - induced ethane exhalation. 36th SOT Annual Meeting, Cincinnati, OH (1997). Toxicologist 36: 300 (1529) 1997.
80.Channel, S.R., Byczkowski, J.Z., Schmidt, W.J., Miller, C.R.: Experimental verification of the mathematical model of trichloroethylene-induced lipid peroxidation in mouse liver slices. 36th SOT Annual Meeting, Cincinnati, OH (1997). Toxicologist 36: 297 (1511) 1997.
81. Byczkowski, J.Z., Schmidt, W.J., Curran, M.A., Moghaddam, A.P., Seckel, C.S.: Development and experimental calibration of physiologically based pharmacodynamic model for CCl4 - induced ethane exhalation. Conference on Issues and Applications in Toxicology and Risk Assessment. WPAFB, OH, 1997 Abstract Booklet, pp. 92
82. Channel, S.R., Byczkowski, J.Z., Schmidt, W.J., Miller, C.R.: Experimental verification of the mathematical model of trichloroethylene-induced lipid peroxidation in mouse liver slices. Conference on Issues and Applications in Toxicology and Risk Assessment. WPAFB, OH, 1997 Abstract Booklet, pp. 93.
83. Byczkowski, J.Z.: AL/OET Predictive Toxicology Program - dynamic modeling. Conference on Issues and Applications in Toxicology and Risk Assessment. WPAFB, OH, 1997 Abstract Booklet, pp. 91.
84. Byczkowski, J.Z., Curran, M.A., Miller, C.A., Schmidt, W.J.: Dose-response characteristics of lipid peroxidation induced by bromotrichloromethane in B6C3F1 mice. Conference on Issues and Applications in Toxicology and Risk Assessment. WPAFB, OH, 1997 Abstract Booklet, pp. 91.
85.Byczkowski,J.Z.: Biologically based dose-response modeling of oxidative stress induced by chemicals. 106th Annual Meeting of the Ohio Acad. Sci. (1997). Oh. J. Sci. 97: A-9(N) 1997.
86. Byczkowski,J.Z., Channel,S.R. Miller,C.R.: Pharmacodynamic modeling of oxidative stress: mathematical model for lipid peroxidation in vitro. 4th Annual Meeting of the Oxygen Society, San Francisco, CA (1997). Oxygen '97 Program and Abstracts 115 (3-60) 1997.
87. Byczkowski,J.Z., Curran,M.A. , Schmidt,W.J.: Pharmacodynamic modeling of oxidative stress: dose-response characteristics of lipid peroxidation by BrCCl3 in vitro vs in vivo. 4th Annual Meeting of the Oxygen Society, San Francisco, CA (1997). Oxygen '97 Program and Abstracts 114 (3-59) 1997.
88. Byczkowski,J.Z., Curran,M.A., Schmidt,W.J.: Pharmacodynamic modeling of oxidative stress: mathematical model of CCl4 - induced ethane exhalation in vivo. 4th Annual Meeting of the Oxygen Society, San Francisco, CA (1997). Oxygen '97 Program and Abstracts 114 (3-58) 1997.
89. Byczkowski, J.Z., Flemming,C.D.: Pharmacodynamic modeling of oxidative stress: interlinked mathematical model and predicted effects on cellular targets. 4th Annual Meeting of the Oxygen Society, San Francisco, CA (1997). Oxygen '97 Program and Abstracts 114 (3-57) 1997.
90. Lipscomb, J.C., Confer, P. D. & Byczkowski J.Z.: Parameters for a biologically-based model of cytochrome P450 dependent trichloroethylene bioactivation in humans using data from two in vitro systems. The 1997 Midwest Cytochromes P450 Symposium. Purdue University Indianapolis, IN. September 25-26, 1997.
91. Byczkowski, J.Z., Channel, S.R., & Miller, C.R.: Pharmacodynamic modeling of oxidative stress: mathematical model for lipid peroxidation in vitro. Conference on Issues and Applications in Toxicology and Risk Assessment. WPAFB, OH, 1998. Abstract Booklet, pp. 96.
92. Byczkowski, J.Z., Curran, M.A., & Schmidt, W.J.: Pharmacodynamic modeling of oxidative stress: dose-response characteristics of lipid peroxidation by BrCCl3 in vitro vs in vivo. Conference on Issues and Applications in Toxicology and Risk Assessment. WPAFB, OH, 1998. Abstract Booklet, pp. 96.
93. Byczkowski, J.Z., Curran, M.A. & Schmidt, W.J.: Pharmacodynamic modeling of oxidative stress: mathematical model of CCl4 - induced ethane exhalation in vivo. Conference on Issues and Applications in Toxicology and Risk Assessment. WPAFB, OH, 1998. Abstract Booklet, pp. 97.
94. Byczkowski, J.Z. & Flemming, C.D.: Pharmacodynamic modeling of oxidative stress: interlinked mathematical model and predicted effects on cellular targets. Conference on Issues and Applications in Toxicology and Risk Assessment. WPAFB, OH, 1998. Abstract Booklet, pp. 97.
95. Byczkowski, J.Z. & Lipscomb, J.C.: PBPK modeling of oxidative metabolism of TCE in humans: dissection of experimental error and interindividual variability. Conference on Issues and Applications in Toxicology and Risk Assessment. WPAFB, OH, 1998. Abstract Booklet, pp. 97.
96. Byczkowski, J.Z. & Lipscomb, J.C.: Dissection of experimental error and interindividual variability using a Monte Carlo analysis linked with PBPK modeling for oxidative metabolism of TCE in humans. Midwest Users Forum for Population Approaches in Data Analysis, 6th Annual Meeting, Cincinnati, OH, 1998.
97. Byczkowski, J.Z. & Lipscomb, J.C.: The impact of experimental uncertainty and interindividual variability on in vitro to in vivo extrapolation for trichloroethylene metabolism in humans. 38th SOT Annual Meeting, New Orleans, LA (1999). Toxicological Sci. 48: 280 (1322), 1999.
98. Lipscomb,J.C., Fisher, J.W., Confer, P.D. & Byczkowski, J.Z.: In vitro to in vivo extrapolation for trichloroethylene metabolism in humans. 38th SOT Annual Meeting, New Orleans, LA (1999). Toxicological Sci 48: 141 (663).
99. Byczkowski,J.Z., Choudhury,H., Lipscomb,J.C. & Savin,T.J.: A PBPK/Monte Carlo simulation of the heterogeneity in cancer risk assessment for tetrachloroethylene. Conference on Topics in Toxicology and Risk Assessment. WPAFB, OH, 1999. Abstract Booklet, pp. 95.
100. Byczkowski, J.Z. & Lipscomb, J.C.: The impact of experimental uncertainty and interindividual variability on in vitro to in vivo extrapolation for trichloroethylene metabolism in humans. Conference on Topics in Toxicology and Risk Assessment. WPAFB, OH, 1999. Abstract Booklet, pp. 95.
101. Lipscomb,J.C., Fisher, J.W., Confer, P.D. & Byczkowski, J.Z.: In vitro to in vivo extrapolation for trichloroethylene metabolism in humans. Conference on Topics in Toxicology and Risk Assessment. WPAFB, OH, 1999. Abstract Booklet, pp. 103.
102. Rice,G., Mahaffey,K., Lyon,B., Swartout,J., Lipscomb,J., Ueno,Y. & Byczkowski,J.Z.: Methylmercury exposures in the United States: estimates and future directions. Conference on Topics in Toxicology and Risk Assessment. WPAFB, OH, 1999. Abstract Booklet, pp. 67-68.
103. Byczkowski,J.Z. & Lipscomb,J.C: Application of PBPK model for assessment of the lactational transfer of MeHg to nursing infant. Society for Risk Analysis Annual Meeting, Atlanta, GA, 1999, Final Program P1.17, p. 47 (1999).
104. Choudhury,H., Byczkowski,J.Z. & Lipscomb,J.C.: A PBPK/Monte Carlo simulation of the heterogeneity in cancer risk values for tetrachloroethylene. Society for Risk Analysis Annual Meeting, Atlanta, GA, 1999, Final Program M17.07, p. 49 (1999).
105. Byczkowski,J.Z., Choudhury,H. & Lipscomb,J.C.: Physiologically based estimates of the heterogeneity in cancer risk values for tetrachloroethylene. 39th SOT Annual Meeting, Philadelphia, PA (2000). Toxicological Sci. 54: 420 (1978) 2000.
106. Byczkowski, J.Z., Christman, T., Moazed, A., Gifford, M., Tucker, B.: A Framework for Risk-Based Modeling of Cross-Contamination of One Regulated Site by Another. Society for Risk Analysis Annual Meeting, Arlington, VA, 2000, Final Program P2.05, p. 42 (2000).
107. Byczkowski, J.Z., Christman, T., Moazed, A., Gifford, M., Tucker, B.: A Framework for Risk-Based Modeling of Cross-Contamination of One Regulated Site by Another. Conference on Issues and Applications in Toxicology and Risk Assessment. Fairborn, OH, 2001. Abstract Booklet, p. 50.
108. Byczkowski, J.Z.: A Framework and Parameters for Predictive Physiologically Based Modeling of Developmental Toxicants. Society for Risk Analysis Annual Meeting, Seattle, WA, 2001, Final Program W12.1, p. 43 (2001).
109. Byczkowski, J. Z.: Quantitative Methods of Modeling Pharmacokinetics of Metals. Society for Risk Analysis Annual Meeting, New Orleans, LA, 2002, Final Program & Abstracts P2.22, p. 37 (2002).
110. Byczkowski,J.Z.: Quantitative Methods of Modeling Pharmacokinetics of Metals. 2003 Toxicology and Risk Assessment Conference. Fairborn, OH, 2003, Abstract Book, Poster session, p. 33.
111. Byczkowski, J.Z.: Methylmercury Toxicity: on Fish, Children, Pharmacokinetics and Toxicodynamics. Society for Risk Analysis Annual Meeting, Baltimore, MD, 2003, Final Program M21.8, p. 54 (2003).
112. Byczkowski, J.Z.: Methylmercury Toxicity: on Fish, Children, Pharmacokinetics and Toxicodynamics. 2004 Toxicology and Risk Assessment Conference. Cincinnati Marriott North - West Chester, OH, Abstract Book, Poster session, p. 15 (2004).
113. Byczkowski, J.Z.: Methylmercury Reference Dose: Modeling of MeHg Intake by Infants. Society for Risk Analysis Annual Meeting, Palm Springs, CA, 2004, Final Program and Abstracts P1.6, p. 48 (2004).
114. Byczkowski, J.Z.: Population Modeling of Methylmercury Intake by Infants. 2005 Toxicology and Risk Assessment Conference. Fairborn, OH, Abstract Book, Poster session, p. 5 (2005).
115. Byczkowski, J.Z.: Pharmacokinetic Characterization of Potentially Susceptible Subpopulations: Physiologically Based Pharmacokinetic Modeling in Children. Society for Risk Analysis Annual Meeting, Orlando, FL, 2005, Final Program and Abstracts P2.10, p. 50 (2005).
116. Byczkowski, J.Z.: Pharmacokinetic Characterization of Potentially Susceptible Subpopulations: Physiologically Based Pharmacokinetic Modeling in Children. 2006 Toxicology and Risk Assessment Conference. West Chester, OH, Abstract Book, Poster session (2006).
117. Byczkowski, J.Z.: Variability Resulting from Using Different Models in Derivation of Cancer Risk Values. Society for Risk Analysis Annual Meeting, Baltimore, MD, 2006, Final Program M4-P.94, p. 58 (2006).
118. Byczkowski, J.Z.: At What Dose Chloral Hydrate Can Be Really Hazardous to Human Health? Society for Risk Analysis Annual Meeting, San Antonio, TX, 2007, Risk 007: Agents of Analysis M5.74, p. 52 (2007).
119. Byczkowski, J.Z.: At What Dose Chloral Hydrate Can Be Really Hazardous to Human Health? 2008 Toxicology and Risk Assessment Conference. West Chester, OH, Abstract Book, Poster session (2008).
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MATHEMATICAL MODELS AND DATABASES POSTED ON
INTERNET:
1. Byczkowski, J.Z.: Model for Lactational Transfer: LACTMAN. Library of Published Models, URL: http://januszb.110mB.com/PBPK.htm
2. Byczkowski, J.Z.: Model for Lipid Peroxidation in Liver Slices in vitro: LIPOXLIV. Library of Published Models, URL: http://januszb.110mB.com/PBPK.htm
3. Byczkowski, J.Z.: Drugs and Toxic Chemicals in Breast Milk. Database, links and publications, URL: http://JanuszB.110mB.com/milkpage.htm
4. Byczkowski, J.Z.: Pharmacology - Toxicology: Internet Links Useful in Chemical Risk Assessments, URL: http://www.geocities.com/CapeCanaveral/Launchpad/3727/
5. Byczkowski, J.Z.: TCE - initiated lipid peroxidation in liver slices: BBPD model written in ACSL - LPOTCE. Library of Published Models, URL: http://JanuszB.110mB.com/PBPK.htm
6. Byczkowski, J.Z.: Linear PK Model for Cadmium Inhalation - KNOB. Library of Published Models, URL: http://JanuszB.110mB.com/PBPK.htm
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* SOME INVITED PRESENTATIONS:
1.Byczkowski,J.Z.: Mode of action of p,p'-DDT on mitochondrial bioenergetics. Virginia Polytechnic Institute, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Tech, Blackburg, VA. 8/11/87.
2.Byczkowski,J.Z.: Reactive free-radical oxygen species and benzo(a)pyrene metabolism in microsomes. University of Pennsylvania, School of Medicine, Department of Pharmacology, Philadelphia, PA. 8/21/87.
3.Byczkowski,J.Z.: Benzo(a)pyrene metabolism by free-radicals. Kansas State University, Division of Biology, Manhattan, KS. 10/9/87.
4.Byczkowski,J.Z.: Free-radical oxygen and benzo(a)pyrene microsomal metabolism. Wayne State University, College of Pharmacy and Allied Health Professions, Department of Pharmaceutical Sciences, Detroit, MI. 10/27/87.
5.Byczkowski,J.Z.: Bio-activation of benzo(a)pyrene by novel pathways. University of South Florida, College of Public Health, Tampa, FL. 1/23/89.
6.Byczkowski,J.Z.: Novel pathways for activation of benzo(a)pyrene. Louisiana State University, School of Veterinary Medicine, Department of Veterinary Physiology, Pharmacology and Toxicology, Baton Rouge, LA. 5/22/89.
7.Byczkowski,J.Z.: Free-radical mechanisms in benzo(a)pyrene metabolism. University of South Florida, College of Medicine, Department of Biochemistry and Molecular Biology, Tampa, FL. 10/6/89.
8.Byczkowski,J.Z.: Metabolism of xenobiotic chemicals by co-oxygenation. State University of New York at Buffalo, School of Pharmacy, Department of Biopharmaceutics, Buffalo, N.Y. 1/25/90.
9.Byczkowski,J.Z.: Biochemical toxicology of asbestos-benzo(a)pyrene interaction. University of Missouri-Kansas City, School of Pharmacy, Division of Pharmacology, Kansas City, MO. 4/12/90.
10.Byczkowski,J.Z.: Free-radical pathways in metabolic activation of benzo(a)pyrene. The University of Mississippi Medical Center, Department of Pharmacology and Toxicology, Jackson, MI. 8/9/90.
11.Byczkowski,J.Z.: Oxygen radicals and xenobiotic co-oxygenation. Florida A & M University, College of Pharmacy, Tallahassee FL. 10/2/90.
12.Byczkowski,J.Z.: Reactive oxygen species and bioactivation of xenobiotics. University of Connecticut, Center for Biochemical Toxicology, Storrs, CT. 11/08/90.
13.Byczkowski,J.Z.: Mechanisms of benzo(a)pyrene activation by environmental pollutants. Toxicology Division, Occupational and Environmental Health Directoriate, Armstrong Laboratory, Wright Patterson Air Force Base, OH. 07/16/91.
14.Byczkowski,J.Z.: Lactational transfer of tetrachloroethylene to infant. Wright State Univeristy, Department of Pharmacology and Toxicology, Dayton, OH. 05/26/93.
15.Byczkowski J.Z.: Lipid peroxidation and co-oxygenation of benzo(a)pyrene. Meeting of the Polish Toxicological Society, Gdansk, Poland. 07/21/93.
16.Byczkowski,J.Z.: Linked PBPK model and cancer risk assessment for breast-fed infants. Meeting of the Drug Information Association, Washington, DC. 06/6/94.
17.Byczkowski,J.Z., Pravecek,T., & Channel,S.: Computer simulations of lipid peroxidation in precision cut mouse liver slices and experimental calibration of the mathematical model. AFSOR Predictive Toxicology Program Review, Fairborn, OH. 05/31/95.
18.Byczkowski,J.Z.: Chemically induced oxidative stress. Meeting of the Polish Academy of Science, Warsaw, Poland. 07/26/96.
19.Byczkowski,J.Z.: Chemically induced oxidative stress. Meeting of the Polish Society of Toxicology, Gdansk, Poland. 07/30/96.
20.Byczkowski, J.Z.: Pharmacodynamic modeling of chemically-induced oxidative stress. Fall Meeting of the Ohio Valley SOT, Indianapolis, IN 10/25/96.
21.Byczkowski, J.Z.: Basics of Pharmacodynamic modeling: PBPK and PBPD, Short Course. Workshop "Physiologically Based Pharmacokinetic (PBPK) Modeling" Conference of Issues and Applications in Toxicology and Risk Assessment, WPAFB, OH 4/9/97.
22.Byczkowski, J.Z.: Applying Physiologicaly Based Pharmacokinetic Modeling to Predict Relative Tissue Distribution and Excretion Capacities in Infant, Children, and the Unborn. "Preclinical Drug Development" Barnett International Conference, Philadelphia, PA 11/28-29/01.
23. Byczkowski, J.Z. Problems with Methylmercury: A Crossbreed of Toxicology, Panic and Politics. Meeting of the Polish Society of Toxicology, Gdansk, Poland. 10/04/05.
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